2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Base Information

Chemical Name:2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt
CAS No.:1192313-08-8
Molecular Formula:C₂₆H₃₁F₄N₅O₃*ClH
Molecular Weight:574.018
Hs Code.:

2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Synonyms:2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

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Chemical Property of 2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

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Technology Process of 2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

There total 12 articles about 2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1192313-07-7
2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide

: 1192313-08-8
2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; dichloromethane; for 0.5h; Product distribution / selectivity;

Reference yield:

: 1192313-84-0
1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-N-{2-[(1-methylethyl)amino]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxamide

: 1192313-08-8
2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: PPA / ethanol; toluene / 90 °C

1.2: pH 8

2.1: hydrogenchloride / methanol; diethyl ether; dichloromethane / 0.5 h

With hydrogenchloride; PPA; In methanol; diethyl ether; ethanol; dichloromethane; toluene;

Reference yield:

: 1192313-83-9
lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

: 1192313-08-8
2-[6-[4-fluoro-3-(trifluoromethyl)phenyl]-4-oxo-2-{[3-(1-piperidinyl)propyl]oxy}pyrazolo[1,5-a]pyrazin-5(4H)-yl]-N-(1-methylethyl)acetamide hydrochloride salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.75 h

2.1: PPA / ethanol; toluene / 90 °C

2.2: pH 8

3.1: hydrogenchloride / methanol; diethyl ether; dichloromethane / 0.5 h

With hydrogenchloride; PPA; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;