lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

Base Information

Chemical Name:lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate
CAS No.:1192313-83-9
Molecular Formula:C₂₁H₂₂F₄N₃O₄*Li
Molecular Weight:463.358
Hs Code.:

Synonyms:lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

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Chemical Property of lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

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Technology Process of lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

There total 6 articles about lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1192313-82-8
ethyl 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

: 1192313-83-9
lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

Guidance literature:: With lithium hydroxide monohydrate; In ethanol; water; at 20 ℃; Inert atmosphere of argon;

Reference yield:

: 537050-14-9
2-bromo-1-(4-fluoro-3-(trifluoromethyl)phenyl)ethan-1-one

: 1192313-83-9
lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 5 °C

2: ethanol / 20 °C

3: PPA / toluene / Inert atmosphere of argon

4: potassium carbonate; potassium iodide / acetone / 65 °C / Inert atmosphere of argon; Reflux

5: lithium hydroxide monohydrate / ethanol; water / 20 °C / Inert atmosphere of argon

With PPA; lithium hydroxide monohydrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In ethanol; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1192313-81-7
ethyl 2-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate

: 1192313-83-9
lithium 1-{2-[4-fluoro-3-(trifluoromethyl)phenyl]-2-oxoethyl}-3-{[3-(1-piperidinyl)propyl]oxy}-1H-pyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / acetone / 65 °C / Inert atmosphere of argon; Reflux

2: lithium hydroxide monohydrate / ethanol; water / 20 °C / Inert atmosphere of argon

With lithium hydroxide monohydrate; potassium carbonate; potassium iodide; In ethanol; water; acetone;