(S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate

Base Information

Chemical Name:(S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate
CAS No.:47675-78-5
Molecular Formula:C₂₂H₂₈N₂O₆S
Molecular Weight:448.54
Hs Code.:

Synonyms:(S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate

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Chemical Property of (S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate

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Technology Process of (S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate

There total 16 articles about (S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 67-56-1
methanol

: 34235-82-0
N-tosyl-N'-benzyloxycarbonyl-L-lysine

: 47675-78-5
(S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 6h; Heating;
DOI:10.1016/j.tet.2006.07.024

Reference yield:

: 4-[2-oxo-3-(toluene-4-sulfonyl)-oxazolidin-4-yl]-butyraldehyde

: 47675-78-5
(S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C

1.2: sodium cyanoborohydride / tetrahydrofuran / 8 h / 0 - 20 °C

2.1: 99 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 9 h / 20 °C

3.1: hydrogen / Pd(OH)2/C / methanol / 8.5 h / 20 °C / 760 Torr

4.1: potassium carbonate / tetrahydrofuran; H₂O / 0 - 20 °C

5.1: 78 percent / Jones' reagent / acetone / 8 h / 0 - 20 °C

6.1: 90 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With lithium hydroxide; jones' reagent; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; water; acetone; benzene;
DOI:10.1016/j.tet.2006.07.024

Reference yield:

: 912806-74-7
(S)-(+)-N-tosyl-4-(4',4'-diethoxybutyl)-1,3-oxazolidin-2-one

: 47675-78-5
(S)-methyl 6-(((benzyloxy)carbonyl)amino)-2-(4-methylphenylsulfonamido)hexanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: HCl / tetrahydrofuran / 0.5 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C

2.2: sodium cyanoborohydride / tetrahydrofuran / 8 h / 0 - 20 °C

3.1: 99 percent / LiOH*H₂O / tetrahydrofuran; H₂O / 9 h / 20 °C

4.1: hydrogen / Pd(OH)2/C / methanol / 8.5 h / 20 °C / 760 Torr

5.1: potassium carbonate / tetrahydrofuran; H₂O / 0 - 20 °C

6.1: 78 percent / Jones' reagent / acetone / 8 h / 0 - 20 °C

7.1: 90 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With hydrogenchloride; lithium hydroxide; jones' reagent; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; water; acetone; benzene;
DOI:10.1016/j.tet.2006.07.024