di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate

Base Information

Chemical Name:di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate
CAS No.:1037834-52-8
Molecular Formula:C₃₂H₄₁FN₂O₈
Molecular Weight:600.685
Hs Code.:

Synonyms:di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate

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Chemical Property of di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate

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Technology Process of di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate

There total 5 articles about di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1037834-51-7
di-tert-butyl [2-amino-4-fluoro-5-(methoxycarbonyl)phenyl]malonate

: 1037834-52-8
di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate

Guidance literature:: benzyl 4-oxo-1-piperidinecarboxylate; di-tert-butyl [2-amino-4-fluoro-5-(methoxycarbonyl)phenyl]malonate; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;

With water; sodium hydrogencarbonate; In 1,2-dichloro-ethane;

Reference yield:

: 924868-81-5
methyl 2,5-difluoro-4-nitrobenzoate

: 1037834-52-8
di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: nickel / methanol

3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; nickel; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 541-16-2
t-butyl malonate

: 1037834-52-8
di-tert-butyl [2-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-4-fluoro-5-(methoxycarbonyl)phenyl]malonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: nickel / methanol

3.1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; nickel; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;