3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Base Information

Chemical Name:3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester
CAS No.:315688-10-9
Molecular Formula:C₂₈H₃₄F₄N₂O₇
Molecular Weight:586.581
Hs Code.:

Synonyms:3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

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Chemical Property of 3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

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Technology Process of 3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

There total 4 articles about 3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 315688-09-6
3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

: 315688-10-9
3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: 3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester; With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 0.5h; Inert atmosphere;

With potassium dihydrogenphosphate; In tetrahydrofuran;

Reference yield:

: 769-39-1,85303-67-9
2,3,5,6-tetraflourophenol

: 315688-10-9
3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium fluoride / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Inert atmosphere

With potassium fluoride; sodium tetrahydroborate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: Z-Val-Asp(O-tBu)-OH

: 315688-10-9
3-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 0 °C

1.3: 2 h / 0 - 20 °C

2.1: potassium fluoride / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / Inert atmosphere

With 4-methyl-morpholine; potassium fluoride; sodium tetrahydroborate; isobutyl chloroformate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;