(R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

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Chemical Name:(R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate
CAS No.:1311374-53-4
Molecular Formula:C₃₃H₃₄BrClF₃N₃O₅S₂
Molecular Weight:789.134
Hs Code.:

(R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Synonyms:(R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

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Chemical Property of (R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

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Technology Process of (R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

There total 20 articles about (R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1239957-04-0
(R)-methyl 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

: 109-64-8
1,3-dibromo-propane

: 1311374-53-4
(R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃; for 4h;

Reference yield:

: 16817-43-9
5-Bromo-2-chloroanisole

: 1311374-53-4
(R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Guidance literature:: Multi-step reaction with 16 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / toluene; hexane / 0.33 h / 0 - 15 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: potassium trimethylsilonate / tert-butyl methyl ether; tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

2.2: pH 1

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h

4.1: tetrahydrofuran / 2 h / -78 - 20 °C

5.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

6.1: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

7.1: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

8.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

9.1: acetic acid / 4 h / Reflux

10.1: caesium carbonate / acetonitrile / 2 h

11.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

12.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 0 - 80 °C

13.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

14.1: hydrogenchloride; sodium nitrite; acetic acid / water / 4 - 6 °C

14.2: 1.33 h / 5 °C

15.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1.5 h / Reflux

15.2: 0.75 h / 0 °C

16.1: potassium carbonate / acetonitrile / 4 h / 60 °C

With hydrogenchloride; dmap; n-butyllithium; thionyl chloride; sodium azide; tetra-n-butylammonium tribromide; diphenyl phosphoryl azide; potassium trimethylsilonate; hydrogen; potassium carbonate; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; N-cyclohexyl-cyclohexanamine; trifluoroacetic acid; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1239963-79-1
2-(4-chloro-3-methoxyphenyl)-N-methoxy-N,2-dimethylpropanamide

: 1311374-53-4
(R)-methyl 2-(N-(3-bromopropyl)-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorophenylsulfonamido)propanoate

Guidance literature:: Multi-step reaction with 13 steps

1.1: tetrahydrofuran / 2 h / -78 - 20 °C

2.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 3 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4.1: hydrogenchloride; hydrogen / platinum(IV) oxide / methanol / 5 h / 3361.55 Torr

5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6.1: acetic acid / 4 h / Reflux

7.1: caesium carbonate / acetonitrile / 2 h

8.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

9.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 0 - 80 °C

10.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

11.1: hydrogenchloride; sodium nitrite; acetic acid / water / 4 - 6 °C

11.2: 1.33 h / 5 °C

12.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 1.5 h / Reflux

12.2: 0.75 h / 0 °C

13.1: potassium carbonate / acetonitrile / 4 h / 60 °C

With hydrogenchloride; thionyl chloride; sodium azide; tetra-n-butylammonium tribromide; diphenyl phosphoryl azide; hydrogen; potassium carbonate; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium nitrite; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;