N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

Base Information

Chemical Name:N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester
CAS No.:875433-34-4
Molecular Formula:C₄₁H₅₄N₄O₆
Molecular Weight:698.903
Hs Code.:

Synonyms:N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

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Chemical Property of N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

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Technology Process of N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

There total 4 articles about N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 110-91-8,99108-56-2
morpholine

: 875433-33-3
N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

: 875433-34-4
N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 24h; Heating;
DOI:10.1021/jo0521910

Reference yield:

: 875433-31-1
(2S)-N-[9-(4-bromophenyl)-9-fluorenyl]alanine tert-butyl ester

: 875433-34-4
N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / zinc bromide / CH₂Cl₂ / 24 h / 20 °C

2: 75 percent / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / 24 h

3: 78 percent / palladium(II) acetate; (+/-)-BINAP; Cs₂CO₃ / toluene / 24 h / Heating

With palladium diacetate; benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dicyclohexyl-carbodiimide; zinc dibromide; In dichloromethane; toluene;
DOI:10.1021/jo0521910

Reference yield:

: 225098-19-1
N-[9-(4-bromophenyl)-9-fluorenyl]alanine methyl ester

: 875433-34-4
N-(9-(4-morpholinophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / lithium hydroxide / dioxane; H₂O

2: 75 percent / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / 24 h

3: 78 percent / palladium(II) acetate; (+/-)-BINAP; Cs₂CO₃ / toluene / 24 h / Heating

With lithium hydroxide; palladium diacetate; benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dicyclohexyl-carbodiimide; In 1,4-dioxane; water; toluene;
DOI:10.1021/jo0521910