N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

Base Information

Chemical Name:N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester
CAS No.:875433-33-3
Molecular Formula:C₃₇H₄₆BrN₃O₅
Molecular Weight:692.693
Hs Code.:

Synonyms:N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

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Technology Process of N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

There total 3 articles about N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 14529-23-8
(S)-2-Amino-6-tert-butoxycarbonylamino-hexanoic acid tert-butyl ester

: 225098-20-4
(2S)-N-[9-(4-bromophenyl)-9-fluorenyl]alanine

: 875433-33-3
N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; for 24h;
DOI:10.1021/jo0521910

Reference yield:

: 875433-31-1
(2S)-N-[9-(4-bromophenyl)-9-fluorenyl]alanine tert-butyl ester

: 875433-33-3
N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / zinc bromide / CH₂Cl₂ / 24 h / 20 °C

2: 75 percent / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / 24 h

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; zinc dibromide; In dichloromethane;
DOI:10.1021/jo0521910

Reference yield:

: 225098-19-1
N-[9-(4-bromophenyl)-9-fluorenyl]alanine methyl ester

: 875433-33-3
N-(9-(4-bromophenyl)-9-fluorenyl)alaninyl-ω-N-(tert-butoxycarbonyl)lysine tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / lithium hydroxide / dioxane; H₂O

2: 75 percent / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / 24 h

With lithium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; water;
DOI:10.1021/jo0521910