methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

Base Information

Chemical Name:methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid
CAS No.:1434631-76-1
Molecular Formula:C₂₅H₂₇N₃O₆S
Molecular Weight:497.572
Hs Code.:

Synonyms:methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

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Chemical Property of methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

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Technology Process of methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

There total 12 articles about methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1403759-74-9
2-(tripropylstannyl)-1,3-oxazole

: 1434643-49-8
C₂₂H₂₅BrN₂O₅S

: 1434631-76-1
methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; acetonitrile; at 0 - 20 ℃; for 1h; Inert atmosphere; Reflux;

Reference yield:

: 4815-30-9
diethyl 5-amino-3-methyl-2,4-thiophenedicarboxylate

: 1434631-76-1
methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / 1,4-dioxane / 0.25 h / 10 °C

1.2: 10 - 100 °C

2.1: sodium hydroxide; water / methanol / 4 h / 50 °C

3.1: potassium carbonate; silver(I) acetate; 1-methyl-pyrrolidin-2-one / 2 h / 110 °C

4.1: bromine; CH₃COONa / acetic acid / 1 h / 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere; Reflux

With 1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; CH₃COONa; water; bromine; silver(I) acetate; sodium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetic acid; toluene; acetonitrile;

Reference yield:

: 1434655-18-1
tert-butyl 2-isocyanato-2-methylpropanoate

: 1434631-76-1
methyl-2-[5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1-[(2S)-2-phenyl-2-(propan-2-yloxy)ethyl]-1H,2H,3H,4H-thieno[2,3-d]pyrimidin-3-yl]propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / 1,4-dioxane / 0.25 h / 10 °C

1.2: 10 - 100 °C

2.1: sodium hydroxide; water / methanol / 4 h / 50 °C

3.1: potassium carbonate; silver(I) acetate; 1-methyl-pyrrolidin-2-one / 2 h / 110 °C

4.1: bromine; CH₃COONa / acetic acid / 1 h / 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere; Reflux

With 1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; CH₃COONa; water; bromine; silver(I) acetate; sodium hydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetic acid; toluene; acetonitrile;