6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate

Base Information

Chemical Name:6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate
CAS No.:1428249-16-4
Molecular Formula:C₂₄H₂₂F₄N₈
Molecular Weight:498.486
Hs Code.:

Synonyms:6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate

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Chemical Property of 6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate

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Technology Process of 6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate

There total 3 articles about 6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428248-69-4
5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

: 1428249-16-4
6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; Sealed tube;
DOI:10.1016/j.bmcl.2021.128352

Reference yield:

: 1083051-56-2
6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

: 1428249-16-4
6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / Microwave irradiation

2: palladium diacetate; caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 100 °C / Sealed tube

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; caesium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2021.128352

Reference yield:

: 1428249-16-4
6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)-5-pyrimidin-4-ylpyrimidin-4-amine trifluoroacetate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water; acetone;