5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

Base Information

Chemical Name:5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine
CAS No.:1428248-69-4
Molecular Formula:C₂₀H₁₉BrF₄N₆
Molecular Weight:499.309
Hs Code.:

Synonyms:5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

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Chemical Property of 5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

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Technology Process of 5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

There total 1 articles about 5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1083051-56-2
6-(4-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl-piperidin-1-yl)pyrimidin-4-amine

: 663193-80-4
5-bromo-6-chloro-pyrimidin-4-ylamine

: 1428248-69-4
5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 60 ℃;

Reference yield: 74.0%

: 1428248-69-4
5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

: 1765-93-1
4-fluoroboronic acid

: 5-(4-fluorophenyl)-6-{4-[4-(4-fluoro-3-trifluoromethylphenyl)-1-methyl-1H-imidazol-2-yl]piperidin-1-yl}pyrimidin-4-ylamine hydrochloride

Guidance literature:: 5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine; 4-fluoroboronic acid; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water; acetone;

Reference yield:

: 1428248-69-4
5-bromo-6-(4-{4-[4-fluoro-3-(trifluoromethyl)-phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

: 1765-93-1
4-fluoroboronic acid

: 5-(4-fluorophenyl)-6-(4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}piperidin-1-yl)pyrimidin-4-amine

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; Sealed tube;
DOI:10.1016/j.bmcl.2021.128352