Technology Process of (2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide
There total 12 articles about (2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
![(2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide](/Databaselist/images/loading.webp)
-
1315325-71-3
(2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide
- Guidance literature:
-
Hoveyda-Grubbs catalyst second generation;
In
dichloromethane;
at 40 ℃;
-
-
1315325-71-3
(2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridine / tetrahydrofuran / 0 - 20 °C
2.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C
2.2: pH ~ 2
3.1: trichlorophosphate / 1,4-dioxane / 2 h / 0 - 110 °C
3.2: pH ~ 9
4.1: sodium t-butanolate / dimethylsulfoxide-d6 / 2 h / 0 - 20 °C
4.2: 1 h / 20 °C
4.3: pH ~ 3
5.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 6 h / 0 - 20 °C
6.1: thionyl chloride / methanol / 2 h / 0 - 45 °C
7.1: benzotriazol-1-ol; HATU / dichloromethane / 5 h / 20 °C
8.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 40 °C
With
4-methyl-morpholine; pyridine; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate;
Hoveyda-Grubbs catalyst second generation;
In
tetrahydrofuran; 1,4-dioxane; methanol; dimethylsulfoxide-d6; dichloromethane; water; tert-butyl alcohol;
-
-
1315325-71-3
(2R,6S,13aS,14aR,16aS,Z)-N-(cyclopropylsulfonyl)-6-(4-fluorophenylamino)-2-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxamide
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C
1.2: 3 h / 80 °C
2.1: potassium tert-butylate / tert-butyl alcohol / 3 h / 80 °C
3.1: pyridine / tetrahydrofuran / 0 - 20 °C
4.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C
4.2: pH ~ 2
5.1: trichlorophosphate / 1,4-dioxane / 2 h / 0 - 110 °C
5.2: pH ~ 9
6.1: sodium t-butanolate / dimethylsulfoxide-d6 / 2 h / 0 - 20 °C
6.2: 1 h / 20 °C
6.3: pH ~ 3
7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 6 h / 0 - 20 °C
8.1: thionyl chloride / methanol / 2 h / 0 - 45 °C
9.1: benzotriazol-1-ol; HATU / dichloromethane / 5 h / 20 °C
10.1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 40 °C
With
4-methyl-morpholine; pyridine; thionyl chloride; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; HATU; sodium t-butanolate; trichlorophosphate;
Hoveyda-Grubbs catalyst second generation;
In
tetrahydrofuran; 1,4-dioxane; methanol; dimethylsulfoxide-d6; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
