54802-10-7Relevant articles and documents
A benzofuran-β-Alaninamide based "turn-on" fluorescent chemosensor for selective recognition of Fe3+ ions
Madhu,Sivakumar,Sribalan, Rajendran
, p. 14426 - 14434 (2019/09/30)
A benzofuran-β-Alaninamide based chemosensor, 3-(3-((4-methylbenzyl)amino)propanamido)benzofuran-2-carboxamide (BAA), was designed and synthesized for selective detection of Fe3+ ions. The binding ability of BAA towards Fe3+ in DMSO/
The design, synthesis, and biological evaluation of PIM kinase inhibitors
Tsuhako, Amy Lew,Brown, David S.,Koltun, Elena S.,Aay, Naing,Arcalas, Arlyn,Chan, Vicky,Du, Hongwang,Engst, Stefan,Franzini, Maurizio,Galan, Adam,Huang, Ping,Johnston, Stuart,Kane, Brian,Kim, Moon H.,Douglas Laird,Lin, Rui,Mock, Lillian,Ngan, Iris,Pack, Michael,Stott, Gordon,Stout, Thomas J.,Yu, Peiwen,Zaharia, Cristiana,Zhang, Wentao,Zhou, Peiwen,Nuss, John M.,Kearney, Patrick C.,Xu, Wei
scheme or table, p. 3732 - 3738 (2012/07/17)
A series of substituted benzofuropyrimidinones with pan-PIM activities and excellent selectivity against a panel of diverse kinases is described. Initial exploration identified aryl benzofuropyrimidinones that were potent, but had cell permeability limitation. Using X-ray crystal structures of the bound PIM-1 complexes with 3, 5m, and 6d, we were able to guide the SAR and identify the alkyl benzofuropyrimidinone (6l) with good PIM potencies, permeability, and oral exposure.
Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity
Ando, Kumiko,Tsuji, Eriko,Ando, Yuko,Kuwata, Noriko,Kunitomo, Jun-Ichi,Yamashita, Masayuki,Ohta, Shunsaku,Kohno, Shigekatsu,Ohishi, Yoshitaka
, p. 625 - 635 (2007/10/03)
Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.