54802-10-7

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Aminobenzofuran-2-carboxamide 97 is utilized as a key intermediate in the production of various pharmaceuticals. Its unique structure and functional groups allow for the creation of complex molecules with potential therapeutic properties.
Used in Organic Compound Production:
In the chemical industry, 3-Aminobenzofuran-2-carboxamide 97 serves as an essential building block for the synthesis of a wide range of organic compounds. Its presence in these compounds can contribute to their specific chemical and physical properties.
Used in Research Applications:
Due to its high purity, 3-Aminobenzofuran-2-carboxamide 97 is an ideal candidate for research purposes. It can be employed in the development of new chemical reactions, the study of its reactivity with other compounds, and the exploration of its potential applications in various fields.
Used in Industrial Applications:
The high purity of 3-Aminobenzofuran-2-carboxamide 97 makes it suitable for use in industrial processes, where it can be incorporated into the production of various products, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its versatility and reactivity contribute to the efficiency and effectiveness of these processes.

InChI:InChI=1/C9H8N2O2/c10-7-5-3-1-2-4-6(5)13-8(7)9(11)12/h1-4H,10H2,(H2,11,12)

Upstream product

• 611-20-1 salicylonitrile 
• 49615-99-8 (2-cyanophenoxy)acetonitrile 
• 54802-12-9 2-(2-cyanophenoxy)acetamide 

Downstream Products

• 68217-76-5 3-benzoyl-2-phenyl-3H-benzo[4,5]furo[3,2-d]pyrimidin-4-one 
• 39786-36-2 4-oxo-3,4-dihydrobenzofuro<3,2-d>pyrimidine 
• 62208-68-8 1,2,3,4-Tetrahydro-2,4-dioxobenzofuro<3,2-d>pyrimidine 
• 78202-04-7 3-phthalimidobenzofuran-2-carboxamide 
• 78201-99-7 3-phthalamidobenzofuran-2-carboxamide 
• 117838-33-2 3-{[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-amino}-benzofuran-2-carboxylic acid amide 
• 117838-39-8 2-(3-Nitro-phenyl)-3H-benzo[4,5]furo[3,2-d]pyrimidin-4-one 
• 117838-31-0 3-{[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-amino}-benzofuran-2-carboxylic acid amide 
• 117838-37-6 2-(4-nitriphenyl)-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidine 
• 117838-27-4 3-N-(benzylideneamino)benzofuran-2-carboxamide 
• 33149-53-0 3,4-dihydro-2-phenyl-4-oxobenzofuro<3,2-d>pyrimidine 
• 121997-01-1 3-(4-methoxyphenyl)benzofuro<3,2-d>pyrimidin-2,4(1H,3H)-dione 
• 39876-88-5 4-Chlorobenzofuro<3,2-d>pyrimidine 
• 62208-74-6 4-benzylsulfanyl-benzo[4,5]furo[3,2-d]pyrimidine 

Relevant academic research and scientific papers

A benzofuran-β-Alaninamide based "turn-on" fluorescent chemosensor for selective recognition of Fe3+ ions

A benzofuran-β-Alaninamide based chemosensor, 3-(3-((4-methylbenzyl)amino)propanamido)benzofuran-2-carboxamide (BAA), was designed and synthesized for selective detection of Fe3+ ions. The binding ability of BAA towards Fe3+ in DMSO/

Discovery of XL413, a potent and selective CDC7 inhibitor

CDC7 is a serine/threonine kinase that has been shown to be required for the initiation and maintenance of DNA replication. Up-regulation of CDC7 is detected in multiple tumor cell lines, with inhibition of CDC7 resulting in cell cycle arrest. In this paper, we disclose the discovery of a potent and selective CDC7 inhibitor, XL413 (14), which was advanced into Phase 1 clinical trials. Starting from advanced lead 3, described in a preceding communication, we optimized the CDC7 potency and selectivity to demonstrate in vitro CDC7 dependent cell cycle arrest and in vivo tumor growth inhibition in a Colo-205 xenograft model.

The design, synthesis, and biological evaluation of PIM kinase inhibitors

A series of substituted benzofuropyrimidinones with pan-PIM activities and excellent selectivity against a panel of diverse kinases is described. Initial exploration identified aryl benzofuropyrimidinones that were potent, but had cell permeability limitation. Using X-ray crystal structures of the bound PIM-1 complexes with 3, 5m, and 6d, we were able to guide the SAR and identify the alkyl benzofuropyrimidinone (6l) with good PIM potencies, permeability, and oral exposure.

HCV PROTEASE INHIBITORS

This invention relates to compounds of Formula (I), (II), or (III) shown in the specification. These compounds can be used to treat hepatitis C virus infection.

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity

Novel 3-acetoacetylaminobenzo[b]furan derivatives having a modified triene system at the 3-position were synthesized starting with 3-aminobenzo[b]furans. The enol isomers, 3-[(3-hydroxybul-2-enonyl)amino]benzo[b]furans (1), of the 3-acetoacetylaminobenzo[b]furans were obtained as stable isomers owing to formation of a hydrogen bonding between the enol hydroxyl group and the amidocarbonyl group. The planarity of the C-2 substituent through the C-3 side chain suggested the existence of a modified conjugational triene system in the enol compound. Cysteinyl leukotriene 1 and 2 receptor antagonistic activities for these compounds were evaluated. 2-(4-Cyanobenzoyl or ethoxycarbonyl)-3-[(2-cyano-3-hydroxybut-2-enonyl)amino]benzo[e]furans (15g, 15o, 15u) were moderately active.

3-thio or amino substituted-benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted-benzofuran-2-carboxamides as inhibitors of cell adhesion

3-Thio or amino substituted benzo[b]thiophene-2-carboxamides and 3-oxygen, thio, or amino substituted benzofuran-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agent