p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Base Information

Chemical Name:p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate
CAS No.:77597-20-7
Molecular Formula:C₃₉H₄₃N₂O₆PS₃Si
Molecular Weight:791.037
Hs Code.:

p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Synonyms:p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

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Chemical Property of p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

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Technology Process of p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

There total 4 articles about p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 77597-16-1
p-nitrobenzyl 2-<4-<<<(2-hydroxyethyl)thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

: 77597-20-7
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 0.333333h; ice-cooling;

Reference yield:

: 77597-10-5
4-<<<<2-<(tetrahydropyran-2-yl)oxy>ethyl>thio>thiocarbonyl>thio>-2-azetidinone

: 77597-20-7
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / benzene / 9 h / Heating

2: 1.) 2,6-lutidine, thionyl chloride; 2.) 2,6-lutidine / 1.) THF, -10 deg C, 30 min; 2.) THF, -10 deg C, then 50 deg C, 11 h

3: 98 percent / p-toluenesulfonic acid (hydrate) / tetrahydrofuran; H₂O / 7 h / 50 °C

4: 88 percent / imidazole / dimethylformamide / 0.33 h / ice-cooling

With 1H-imidazole; 2,6-dimethylpyridine; thionyl chloride; toluene-4-sulfonic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; benzene;

Reference yield:

: 77597-12-7
Hydroxy-{2-oxo-4-[2-(tetrahydro-pyran-2-yloxy)-ethylsulfanylthiocarbonylsulfanyl]-azetidin-1-yl}-acetic acid 4-nitro-benzyl ester

: 77597-20-7
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 2,6-lutidine, thionyl chloride; 2.) 2,6-lutidine / 1.) THF, -10 deg C, 30 min; 2.) THF, -10 deg C, then 50 deg C, 11 h

2: 98 percent / p-toluenesulfonic acid (hydrate) / tetrahydrofuran; H₂O / 7 h / 50 °C

3: 88 percent / imidazole / dimethylformamide / 0.33 h / ice-cooling

With 1H-imidazole; 2,6-dimethylpyridine; thionyl chloride; toluene-4-sulfonic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;