4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

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Chemical Name:4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine
CAS No.:1391715-59-5
Molecular Formula:C₅₅H₇₁F₃N₉O₈PSi
Molecular Weight:1102.28
Hs Code.:

4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

Synonyms:4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

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Chemical Property of 4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

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Technology Process of 4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

There total 4 articles about 4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1391715-57-3
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1391715-59-5
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1039/c2ob25647a

Reference yield:

: 1185880-43-6
4-{[(dimethylamino)ethylidene]amino}-3-iodo-1-(5'-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1391715-59-5
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: silver nitrate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1039/c2ob25647a

Reference yield:

: 14719-21-2
trifluoroacetyl-propargyl amine

: 1391715-59-5
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: silver nitrate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; silver nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Sonogashira coupling;
DOI:10.1039/c2ob25647a