4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

Base Information

Chemical Name:4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine
CAS No.:1391715-55-1
Molecular Formula:C₄₀H₄₀F₃N₇O₇
Molecular Weight:787.796
Hs Code.:

4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

Synonyms:4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

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Chemical Property of 4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

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Technology Process of 4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

There total 1 articles about 4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1185880-43-6
4-{[(dimethylamino)ethylidene]amino}-3-iodo-1-(5'-O-(4,4'-dimethoxytriphenylmethyl)-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

: 14719-21-2
trifluoroacetyl-propargyl amine

: 1391715-55-1
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1039/c2ob25647a

Reference yield: 36.0%

: 1391715-55-1
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1391715-57-3
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: With silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1039/c2ob25647a

Reference yield:

: 1391715-55-1
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo[3,4-d]pyrimidine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1391715-59-5
4-{[(dimethylamino)ethylidene]amino}-3-[N'-(2-propynyl)-2,2,2-trifluoroacetamido]-1-(β-D-ribofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-2'-O-(tert-butyldimethylsilyl)-1H-pyrazolo-[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: silver nitrate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1039/c2ob25647a