3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

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Chemical Name:3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid
CAS No.:1356598-77-0
Molecular Formula:C₂₆H₂₃FN₂O₅
Molecular Weight:462.477
Hs Code.:

Synonyms:3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

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Chemical Property of 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

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Technology Process of 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

There total 11 articles about 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356600-21-9
methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

: 1356598-77-0
3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Guidance literature:: methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In water; at 20 ℃; pH=3;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1356598-77-0
3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate; acetic acid / 0.08 h / 20 °C

1.2: 3 h / 20 - 80 °C

2.1: potassium carbonate / acetonitrile / 4 h / 0 - 85 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 0.5 h / 0 °C

4.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: potassium carbonate / acetonitrile / 4 h / 85 °C / Inert atmosphere

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

6.2: 20 °C / pH 3

With methanol; sodium tetrahydroborate; water; sodium acetate; phosphorus tribromide; potassium carbonate; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: 351-54-2
3-fluoro-p-anisaldehyde

: 1356598-77-0
3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 18 h / -78 - 20 °C

1.2: 0 °C

2.1: potassium carbonate / acetonitrile / 4 h / 0 - 85 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 0.5 h / 0 °C

4.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: potassium carbonate / acetonitrile / 4 h / 85 °C / Inert atmosphere

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

6.2: 20 °C / pH 3

With methanol; sodium tetrahydroborate; water; boron tribromide; phosphorus tribromide; potassium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;