methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

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Chemical Name:methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate
CAS No.:1356600-21-9
Molecular Formula:C₂₇H₂₅FN₂O₅
Molecular Weight:476.504
Hs Code.:

Synonyms:methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

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Chemical Property of methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

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Technology Process of methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

There total 10 articles about methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.25%

: 1356600-20-8,1356600-66-2,1356600-68-4
methyl 3-cyano-3-(4-hydroxyphenyl)propanoate

: 1356600-19-5
(1E,1Z)-2-[4-(bromomethyl)-2-fluorophenoxy]-1-phenylethanone O-methyloxime

: 1356600-21-9
methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Guidance literature:: With potassium carbonate; In acetonitrile; at 85 ℃; for 4h; Inert atmosphere;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1356600-21-9
methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium acetate; acetic acid / 0.08 h / 20 °C

1.2: 3 h / 20 - 80 °C

2.1: potassium carbonate / acetonitrile / 4 h / 0 - 85 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 0.5 h / 0 °C

4.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: potassium carbonate / acetonitrile / 4 h / 85 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; sodium acetate; phosphorus tribromide; potassium carbonate; acetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 351-54-2
3-fluoro-p-anisaldehyde

: 1356600-21-9
methyl 3-cyano-3-{4-[(3-fluoro-4-{[(2E,2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 18 h / -78 - 20 °C

1.2: 0 °C

2.1: potassium carbonate / acetonitrile / 4 h / 0 - 85 °C / Inert atmosphere

3.1: sodium tetrahydroborate; methanol / 0.5 h / 0 °C

4.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.1: potassium carbonate / acetonitrile / 4 h / 85 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; boron tribromide; phosphorus tribromide; potassium carbonate; In dichloromethane; acetonitrile;