N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide

Base Information

• Chemical Name: N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide
• CAS No.: 107037-70-7
• Molecular Formula: C₉H₇ClF₃NO₃S
• Molecular Weight: 301.674
• Mol file: 107037-70-7.mol

Synonyms:N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide

Chemical Property of N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide

There total 1 articles about N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

phenyl trifluoromethanesulfonamide (456-64-4) + chloroacetyl chloride (79-04-9) → N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide (107037-70-7)

Guidance literature:

With aluminium trichloride; In dichloromethane; at -10 - 20 ℃; for 7h;

DOI:10.1021/jm00387a020

Reference yield: 42.0%

N-Ethylimidazole (7098-07-9) + N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide (107037-70-7) → C13H12F3N3O3S (107037-54-7)

Guidance literature:

In acetonitrile; for 17h; Heating;

DOI:10.1021/jm00387a020

Reference yield:

N-[4-(2-Chloro-acetyl)-phenyl]-C,C,C-trifluoro-methanesulfonamide (107037-70-7) → C13H14F3N3O3S (107037-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / acetonitrile / 17 h / Heating

2: 35 percent / H₂ / 10percent Pd/C / H₂O / 5 h / 2585.7 Torr / Ambient temperature

With hydrogen; palladium on activated charcoal; In water; acetonitrile;

DOI:10.1021/jm00387a020

upstream raw materials:

phenyl trifluoromethanesulfonamide

chloroacetyl chloride

Downstream raw materials:

C₁₃H₁₂F₃N₃O₃S

C₁₃H₁₄F₃N₃O₃S