L-H-Phe(4-B(OH)2)-OMe

Base Information

• Chemical Name: L-H-Phe(4-B(OH)2)-OMe
• CAS No.: 177797-94-3
• Molecular Formula: C₁₀H₁₄BNO₄
• Molecular Weight: 223.036
• Mol file: 177797-94-3.mol

Synonyms:L-H-Phe(4-B(OH)2)-OMe

Chemical Property of L-H-Phe(4-B(OH)2)-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of L-H-Phe(4-B(OH)2)-OMe

There total 1 articles about L-H-Phe(4-B(OH)2)-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + p-borono-L-phenylalanine (76410-58-7) → L-H-Phe(4-B(OH)2)-OMe (177797-94-3)

Guidance literature:

With hydrogenchloride; In water; for 2h; Heating;

DOI:10.1021/ol025547s

Reference yield:

L-H-Phe(4-B(OH)2)-OMe (177797-94-3) → N-(tert-butoxycarbonyl)-4-{1,3-bis(tert-butoxycarbonyl)-3-[2-(trimethylsilyl)ethoxymethyl]}amidino-L-phenylalanine, methyl ester (412024-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran; H₂O / 3 h / 20 °C / pH 9.5

2: 54 percent / copper(I) thiophene-2-carboxylate; tris(2-furyl)phosphine / Pd₂dba3*CHCl₃ / dioxane / 16 h / 65 °C

With copper(I) thiophene-2-carboxylate; trifuran-2-yl-phosphane; sodium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1021/ol025547s

Reference yield:

L-H-Phe(4-B(OH)2)-OMe (177797-94-3) → 4-amidino-L-phenylalanine, methyl ester, bis-trifluoroacetate

Guidance literature:

Multi-step reaction with 3 steps

1: sodium carbonate / tetrahydrofuran; H₂O / 3 h / 20 °C / pH 9.5

2: 54 percent / copper(I) thiophene-2-carboxylate; tris(2-furyl)phosphine / Pd₂dba3*CHCl₃ / dioxane / 16 h / 65 °C

3: 62 percent / CH₂Cl₂ / 12 h / 20 °C

With copper(I) thiophene-2-carboxylate; trifuran-2-yl-phosphane; sodium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

DOI:10.1021/ol025547s

upstream raw materials:

methanol

p-borono-L-phenylalanine

Downstream raw materials:

(S)-(4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)phenyl)boronic acid

4-(2-diazolyl)-L-phenylalanine methyl ester

C₂₀⁽¹³⁾CH₂₄⁽²⁾H₃N₃O₄S

N-(tert-butoxycarbonyl)-4-{1,3-bis(tert-butoxycarbonyl)-3-[2-(trimethylsilyl)ethoxymethyl]}amidino-L-phenylalanine, methyl ester

Refernces