cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide

Base Information

Chemical Name:cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide
CAS No.:952421-56-6
Molecular Formula:C₂₀H₂₈F₃N₃O₄S₂
Molecular Weight:495.587
Hs Code.:

Synonyms:cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide

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Chemical Property of cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide

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Technology Process of cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide

There total 10 articles about cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: cyclopropanesulfonic acid (2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide

: 952421-56-6
cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 952506-25-1
2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine

: 952421-56-6
cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dmap / 1,2-dichloro-ethane / 2 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; triethylamine; dmap; In 1,4-dioxane; 1,2-dichloro-ethane;

Reference yield:

: 532-24-1
tropinone

: 952421-56-6
cyclopropanesulfonic acid (2-{3-exo-[(R)-1-amino-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / toluene / 16 h / Heating / reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -40 - 0 °C

2.2: 0.5 h / -40 - 0 °C

3.1: hydrogenchloride; water / acetone / 24 h / 50 °C

4.1: pyridinium p-toluenesulfonate; magnesium sulfate / 1,2-dichloro-ethane / 1 h

4.2: 16 h / 50 °C

5.1: magnesium / diethyl ether / 0.5 h / 20 °C

5.2: 4 h / 0 - 20 °C

5.3: 0 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

7.1: sodium hydroxide / dichloromethane; water / 16 h / 50 °C

8.1: hydrazine / ethanol / 12 h / 20 °C

9.1: triethylamine / dmap / 1,2-dichloro-ethane / 2 h / 20 °C

10.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; water; hydrogen; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; magnesium sulfate; potassium carbonate; magnesium; triethylamine; hydrazine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetone; toluene;