2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine

Base Information

Chemical Name:2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine
CAS No.:952506-25-1
Molecular Formula:C₂₁H₃₂F₃N₃O₃S₂
Molecular Weight:495.631
Hs Code.:

Synonyms:2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine

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Chemical Property of 2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine

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Technology Process of 2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine

There total 7 articles about 2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952506-24-0
N-(2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethyl)-phthalimide

: 952506-25-1
2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine

Guidance literature:: With hydrazine; In ethanol; at 20 ℃; for 12h;

Reference yield:

: 532-24-1
tropinone

: 952506-25-1
2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / toluene / 16 h / Heating / reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -40 - 0 °C

2.2: 0.5 h / -40 - 0 °C

3.1: hydrogenchloride; water / acetone / 24 h / 50 °C

4.1: pyridinium p-toluenesulfonate; magnesium sulfate / 1,2-dichloro-ethane / 1 h

4.2: 16 h / 50 °C

5.1: magnesium / diethyl ether / 0.5 h / 20 °C

5.2: 4 h / 0 - 20 °C

5.3: 0 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

7.1: sodium hydroxide / dichloromethane; water / 16 h / 50 °C

8.1: hydrazine / ethanol / 12 h / 20 °C

With hydrogenchloride; sodium hydroxide; water; hydrogen; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; magnesium sulfate; potassium carbonate; magnesium; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetone; toluene;

Reference yield:

: 952423-57-3
benzyl 3-formyl-8-azabicyclo[3.2.1]octane-8-carboxylate

: 952506-25-1
2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro-phenyl)-ethyl]-8-aza-bicyclo[3.2.1]octane-8-sulfonyl}-ethylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate; magnesium sulfate / 1,2-dichloro-ethane / 1 h

1.2: 16 h / 50 °C

2.1: magnesium / diethyl ether / 0.5 h / 20 °C

2.2: 4 h / 0 - 20 °C

2.3: 0 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h

4.1: sodium hydroxide / dichloromethane; water / 16 h / 50 °C

5.1: hydrazine / ethanol / 12 h / 20 °C

With sodium hydroxide; hydrogen; pyridinium p-toluenesulfonate; magnesium sulfate; magnesium; hydrazine; palladium 10% on activated carbon; In diethyl ether; ethanol; dichloromethane; water; 1,2-dichloro-ethane;