<(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane

Base Information

Chemical Name:<(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane
CAS No.:138313-18-5
Molecular Formula:C₁₅H₂₇ClOSi
Molecular Weight:286.917
Hs Code.:

Synonyms:<(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of <(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane

There total 3 articles about <(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 96685-53-9
(2Z)-2-<(5S)-5-(tert-butyldimethylsilyloxy)-2-methylene-cyclohexylidene>-ethanol

: 138313-18-5
<(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane

Guidance literature:: With N-chloro-succinimide; dimethylsulfide; 1.) CH₂Cl₂, -20 deg C, 30 min, 2.) 0 deg C, 30 min;
DOI:10.1021/jo00157a004

Reference yield:

: 84927-66-2
7,8-dihydroxy-7,8-dihydrovitamin D₃

: 138313-18-5
<(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: 1.) lead tetraacetate, 2.) Red-Al / 1.) benzene, pyridine, 25 deg C, 10 min, 2.) water, 1,5h

3: 91 percent / N-chlorosuccinimide, dimethyl sulfide / 1.) CH₂Cl₂, -20 deg C, 30 min, 2.) 0 deg C, 30 min

With 1H-imidazole; lead(IV) acetate; N-chloro-succinimide; dimethylsulfide; sodium bis(2-methoxyethoxy)aluminium dihydride; In N,N-dimethyl-formamide;
DOI:10.1021/jo00157a004

Reference yield:

: 84927-67-3
3β-O-(tert-butyldimethylsilyl)-7,8-dihydroxy-7,8-dihydrovitamin D3

: 138313-18-5
<(1Z),(5S)>-2-<5-(t-butyldimethylsilyl)oxy-2-methylenecyclohexylidene>-1-chloroethane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lead tetraacetate, 2.) Red-Al / 1.) benzene, pyridine, 25 deg C, 10 min, 2.) water, 1,5h

2: 91 percent / N-chlorosuccinimide, dimethyl sulfide / 1.) CH₂Cl₂, -20 deg C, 30 min, 2.) 0 deg C, 30 min

With lead(IV) acetate; N-chloro-succinimide; dimethylsulfide; sodium bis(2-methoxyethoxy)aluminium dihydride;
DOI:10.1021/jo00157a004