dicyclohexyl(hydroxymethyl)phosphine oxide

Base Information

• Chemical Name: dicyclohexyl(hydroxymethyl)phosphine oxide
• CAS No.: 34729-69-6
• Molecular Formula: C₁₃H₂₅O₂P
• Molecular Weight: 244.314
• Mol file: 34729-69-6.mol

Synonyms:dicyclohexyl(hydroxymethyl)phosphine oxide

Chemical Property of dicyclohexyl(hydroxymethyl)phosphine oxide

Chemical Property:

Purity/Quality:

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Technology Process of dicyclohexyl(hydroxymethyl)phosphine oxide

There total 3 articles about dicyclohexyl(hydroxymethyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + dicyclohexylphosphine oxide (14717-29-4) → dicyclohexyl(hydroxymethyl)phosphine oxide (34729-69-6)

Guidance literature:

With sodium; In ethanol; for 24h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/jo502623g

Reference yield: 82.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + chlorodicyclohexylphosphane (16523-54-9) → dicyclohexyl(hydroxymethyl)phosphine oxide (34729-69-6)

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.1002/chem.201903625

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + dicyclohexylphosphane (829-84-5) → dicyclohexyl(hydroxymethyl)phosphine oxide (34729-69-6)

Guidance literature:

Multistep reaction; (i) , (ii) O₂, PhSH, H₂O;

upstream raw materials:

formaldehyd

dicyclohexylphosphane

dicyclohexylphosphine oxide

chlorodicyclohexylphosphane

Downstream raw materials:

chloromethyl(dicyclohexyl)phosphine oxide

Refernces

• 1、 Sowa, Sylwia,Stankevi?, Marek,Flis, Anna,Pietrusiewicz, K. Micha?. "Reduction of Tertiary Phosphine Oxides by BH 3 Assisted by Neighboring Activating Groups". . p. 2106 - 2118. Retrieved 2018/02/28.