3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane

Base Information

Chemical Name:3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane
CAS No.:249928-40-3
Molecular Formula:C₄₈H₇₂O₄Si
Molecular Weight:741.183
Hs Code.:

Synonyms:3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane

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Chemical Property of 3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane

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Technology Process of 3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane

There total 4 articles about 3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 200129-83-5
3α-((4-benzoyl)phenylacetyloxy)-6α-hydroxy-5α-cholestane

: 249928-40-3
3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 4h;
DOI:10.1021/jo990800w

Reference yield:

: 26077-80-5
(4-benzoylphenyl)acetic acid

: 249928-40-3
3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / DEAD; PPh₃ / tetrahydrofuran / 0.5 h / 25 °C

2: 92 percent / imidazole / dimethylformamide / 4 h / 25 °C

With 1H-imidazole; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1016/S0040-4020(00)01086-3

Reference yield:

: 41083-73-2
5α-cholestane-3β,6α-diol

: 249928-40-3
3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / DEAD; PPh₃ / tetrahydrofuran / 0.5 h / 25 °C

2: 92 percent / imidazole / dimethylformamide / 4 h / 25 °C

With 1H-imidazole; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Mitsunobu reaction;
DOI:10.1016/S0040-4020(00)01086-3