C₂₂H₂₆N₂O₃

Base Information

• Chemical Name: C₂₂H₂₆N₂O₃
• CAS No.: 1374108-95-8
• Molecular Formula: C₂₂H₂₆N₂O₃
• Molecular Weight: 366.46
• Mol file: 1374108-95-8.mol

Synonyms:C₂₂H₂₆N₂O₃

Chemical Property of C₂₂H₂₆N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₆N₂O₃

There total 4 articles about C₂₂H₂₆N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C36H38N2O3 (1374108-94-7) → C22H26N2O3 (1374108-95-8)

Guidance literature:

With methanesulfonic acid; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

NCI 134652 (31570-97-5) → C22H26N2O3 (1374108-95-8)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride; N,N-dimethyl-formamide / 16.5 h / 20 °C / Cooling with ice

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Cooling with ice

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 7 h / 80 °C / Inert atmosphere

4: methanesulfonic acid / 1 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; methanesulfonic acid; di-isopropyl azodicarboxylate; potassium carbonate; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

2-chloro-5-hydroxyquinoline (124467-35-2) → C22H26N2O3 (1374108-95-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / Cooling with ice

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 7 h / 80 °C / Inert atmosphere

3: methanesulfonic acid / 1 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water;

upstream raw materials:

NCI 134652

2-chloro-5-hydroxyquinoline

C₂₆H₂₄ClNO₃

C₃₆H₃₈N₂O₃

Downstream raw materials:

2-(4-diethylaminophenyl)-5-(2-hydroxy-1-tosyloxymethylethoxy)quinoline