N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide
CAS No.:1425486-40-3
Molecular Formula:C₂₇H₂₃ClF₃N₃O₅S₂
Molecular Weight:626.077
Hs Code.:

Synonyms:N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

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Chemical Property of N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

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Technology Process of N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

There total 7 articles about N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.3%

: 10147-36-1
n-propanesulfonyl chloride

: (3-amino-2,5,6-trifluorophenyl)(3-(4-chlorophenyl)quinoxalin-6-yl)methanone hydrochloride

: 1425486-40-3
N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1425486-40-3
N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride / 1,4-dioxane; water / 4 h / 80 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 1 h / -78 °C

3.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sodium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1425486-37-8
3-(4-chlorophenyl)-N-methoxy-N-methylquinoxaline-6-carboxamide

: 1425486-40-3
N-(3-(3-(4-chlorophenyl)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)-N-(propylsulfonyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1 h / -78 °C

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;