6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one

Base Information

Chemical Name:6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one
CAS No.:1256780-10-5
Molecular Formula:C₃₄H₅₀N₂O₃Si
Molecular Weight:562.868
Hs Code.:

Synonyms:6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one

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Chemical Property of 6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one

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Technology Process of 6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one

There total 4 articles about 6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.3%

: 1256779-87-9
methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate

: 123-30-8
4-amino-phenol

: 1256780-10-5
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: 4-amino-phenol; With trimethylaluminum; In n-heptane; 1,2-dichloro-ethane; at 20 ℃; for 1h; Inert atmosphere;

methyl 3-acetamido-2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-2-heptenate; In n-heptane; 1,2-dichloro-ethane; at 20 ℃; for 15h; Reflux;

Reference yield:

: 137421-55-7
t-butyl-dimethylsilyloxy-2,6-dipropyl-4-hydroxymethyl benzene

: 1256780-10-5
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus tribromide / toluene / 1 h / 20 °C / cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 18 h / 20 °C

3.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

3.2: 14 h / 70 °C

4.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

4.2: 15 h / 20 °C / Reflux

With ammonium acetate; trimethylaluminum; phosphorus tribromide; sodium hydride; acetic acid; In n-heptane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1256779-86-8
methyl 2-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-oxo heptanate

: 1256780-10-5
6-butyl-5-{4-(tert-butyldimethylsilyloxy)-3,5-dipropylbenzyl}-3-(4-hydroxyphenyl)-2-methylpyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / toluene / 5 h / Reflux

1.2: 14 h / 70 °C

2.1: trimethylaluminum / n-heptane; 1,2-dichloro-ethane / 1 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C / Reflux

With ammonium acetate; trimethylaluminum; acetic acid; In n-heptane; 1,2-dichloro-ethane; toluene;