(S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate

Base Information

Chemical Name:(S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate
CAS No.:1403949-83-6
Molecular Formula:C₃₀H₃₈N₂O₅
Molecular Weight:506.642
Hs Code.:

Synonyms:(S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate

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Chemical Property of (S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate

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Technology Process of (S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate

There total 7 articles about (S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 99-66-1
valproic acid

: 1403949-81-4
(S,E)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)acrylate

: 1403949-83-6
(S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate

Guidance literature:: (S,E)-methyl 3-(4-(2-((tert-butoxycarbonyl)amino)-3-(1H-indol-3-yl)propoxy)-3-methoxyphenyl)acrylate; With triethylamine; trifluoroacetic acid; In dichloromethane; for 0.25h;

valproic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃;
DOI:10.1021/ml300366t

Reference yield:

: 1135-24-6,537-98-4
(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

: 1403949-83-6
(S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / 6 h / 80 °C

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h

3.1: triethylamine; trifluoroacetic acid / dichloromethane / 0.25 h

3.2: 20 °C

With toluene-4-sulfonic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2.1: |Mitsunobu Displacement;
DOI:10.1021/ml300366t

Reference yield:

: 2309-07-1
Methyl ferulate

: 1403949-83-6
(S,E)-methyl 3-(4-(3-(1H-indol-3-yl)-2-(2-propylpentanamido)propoxy)-3-methoxyphenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h

2.1: triethylamine; trifluoroacetic acid / dichloromethane / 0.25 h

2.2: 20 °C

With triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 1.1: |Mitsunobu Displacement;
DOI:10.1021/ml300366t