tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Name:tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate
CAS No.:1373279-05-0
Molecular Formula:C₃₅H₃₂F₃N₅O₇S
Molecular Weight:723.73
Hs Code.:

tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Synonyms:tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Property of tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Technology Process of tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

There total 11 articles about tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1373279-04-9
tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1h-benzo[d]imidazol-2-ylthio)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 1373279-05-0
tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 917889-25-9
3-(4-fluoro-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester

: 1373279-05-0
tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

2.2: 16 h / 60 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

6.1: hydroxylamine hydrochloride; pyridine / 2 h / 20 °C

7.1: sodium hypochlorite / dichloromethane / 24 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

9.1: potassium carbonate / acetone / 3 h / 70 °C

10.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With pyridine; sodium hypochlorite; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; dichloromethane; acetone;

Reference yield:

: 1195-45-5
para-fluorophenyl isocyanate

: 1373279-05-0
tert-butyl 5-(7-(5-((5-(difluoromethoxy)-1H-benzo[d]imidazol-2-ylsulfonyl)methyl)isoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

3.2: 16 h / 60 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

6.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; pyridine / 2 h / 20 °C

8.1: sodium hypochlorite / dichloromethane / 24 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

10.1: potassium carbonate / acetone / 3 h / 70 °C

11.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

With pyridine; sodium hypochlorite; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone;