tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Name:tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate
CAS No.:1373279-02-7
Molecular Formula:C₂₇H₂₈FN₃O₅
Molecular Weight:493.535
Hs Code.:

Synonyms:tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Chemical Property of tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

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Technology Process of tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

There total 6 articles about tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1373278-14-8
tert-butyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

: 107-19-7
propargyl alcohol

: 1373279-02-7
tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: With sodium hypochlorite; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 1373279-02-7
tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2.1: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

3.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

3.2: 16 h / 60 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

6.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; pyridine / 2 h / 20 °C

8.1: sodium hypochlorite / dichloromethane / 24 h / 20 °C

With pyridine; sodium hypochlorite; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1373278-09-1
methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

: 1373279-02-7
tert-butyl 5-(3-(4-fluorophenyl)-7-(5-(hydroxymethyl)isoxazol-3-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 0 - 20 °C

1.2: 16 h / 60 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.75 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 68 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride; pyridine / 2 h / 20 °C

6.1: sodium hypochlorite / dichloromethane / 24 h / 20 °C

With pyridine; sodium hypochlorite; lithium hydroxide monohydrate; hydroxylamine hydrochloride; water; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; dichloromethane;