N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

Base Information

Chemical Name:N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)
CAS No.:117023-88-8
Molecular Formula:C₄H₄O₄*2C₂₈H₃₂F₂N₂O₄S
Molecular Weight:1177.35
Hs Code.:

N-<4-<3-<4-<bis(4-fluorophenyl)hydroxymethyl>-1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

Synonyms:N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

Suppliers and Price of N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

Chemical Property:

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Technology Process of N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

There total 8 articles about N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 124-63-0
methanesulfonyl chloride

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 117023-80-0
1-<3-(4-aminophenoxy)propyl>-α,α-bis(4-fluorophenyl)-4-piperidinemethanol

: 117023-88-8
N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

Guidance literature:: With triethylamine; In ethyl acetate; benzene; for 2h; Ambient temperature;
DOI:10.1021/jm00121a022

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 117023-88-8
N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / K₂CO₃ / acetone / 24 h / Heating

2: 73 percent / Na₂CO₃, KI / butan-1-ol / Heating

3: 62 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 2068.6 Torr / Ambient temperature

4: 61 percent / triethylamine / benzene; ethyl acetate / 2 h / Ambient temperature

With hydrogen; sodium carbonate; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; acetone; butan-1-ol; benzene;
DOI:10.1021/jm00121a022

Reference yield:

: 79096-54-1
1-(3-Chloropropoxy)-4-nitrobenzene

: 117023-88-8
N-<4-<3-<4--1-piperidinyl>propoxy>phenyl>methanesulfonamide (E)-2-butenedioate (2:1)

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / Na₂CO₃, KI / butan-1-ol / Heating

2: 62 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 2068.6 Torr / Ambient temperature

3: 61 percent / triethylamine / benzene; ethyl acetate / 2 h / Ambient temperature

With hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; butan-1-ol; benzene;
DOI:10.1021/jm00121a022