N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide
CAS No.:1201842-26-3
Molecular Formula:C₂₃H₁₉ClFN₃O₄S
Molecular Weight:487.939
Hs Code.:

Synonyms:N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

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Chemical Property of N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

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Technology Process of N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

There total 6 articles about N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-86-4,95507-80-5
2-methoxy-ethanol

: 1201841-63-5
N-(2-chloro-5-(4-chloroquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

: 1201842-26-3
N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Guidance literature:: 2-methoxy-ethanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;

N-(2-chloro-5-(4-chloroquinolin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 20h;

Reference yield:

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 1201842-26-3
N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 24 h / 23 °C

2.1: sodium carbonate / Pd fibrecat PPh / 1,4-dioxane / 0.33 h / 120 °C / microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 20 h / 20 °C

With pyridine; sodium hydride; sodium carbonate; Pd fibrecat PPh; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 65340-70-7
6-bromo-4-chloroquinoline

: 1201842-26-3
N-(2-chloro-5-(4-(2-methoxyethoxy)-6-quinolinyl)-3-pyridinyl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 90 °C / Inert atmosphere

2.1: sodium carbonate / Pd fibrecat PPh / 1,4-dioxane / 0.33 h / 120 °C / microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 20 h / 20 °C

With potassium acetate; sodium hydride; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;