588729-99-1

Basic information

• Product Name: 2-Chloro-3-amino-5-bromopyridine
• Synonyms: 5-BROMO-2-CHLORO-3-PYRIDINAMINE;5-BROMO-2-CHLORO-PYRIDIN-3-YLAMINE;5-BROMO-2-CHLOROPYRIDIN-3-AMINE;3-AMINO-5-BROMO-2-CHLOROPYRIDINE;2-Chloro-3-amino-5-bromopyridine;3-Amino-5-bromo-2-chloropyridi;3-Amino-5-Bromo-2-Chloropyrid ;6-(4-fluorophenyl)-2-hydroxynicotinonitrile
• CAS NO: 588729-99-1
• Molecular Formula: C₅H₄BrClN₂
• Molecular Weight: 207.46
• EINECS: -0
• Product Categories: Pyridines ,Halogenated Heterocycles;blocks;Bromides;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Pyridine series;Amines
• Mol File: 588729-99-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 129-132℃
• Boiling Point: 296.778 °C at 760 mmHg
• Flash Point: 133.287 °C
• Appearance: /
• Density: 1.835 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 0.03±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-amino-5-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-amino-5-bromopyridine(588729-99-1)
• EPA Substance Registry System: 2-Chloro-3-amino-5-bromopyridine(588729-99-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-37/38-41-22
• Safety Statements: 26-39-45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 588729-99-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless solid

InChI:InChI=1/C5H4BrClN2/c6-3-1-4(8)5(7)9-2-3/h1-2H,8H2

Upstream product

• 90902-84-4 2,5-dibromopyridin-3-ylamine 
• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 15862-37-0 2,5-dibromo-3-nitro-pyridine 
• 7647-01-0 hydrogenchloride 
• 6945-68-2 5-bromo-3-nitro-pyridin-2-ylamine 
• 15862-34-7 5-bromo-3-nitro-2-pyridone 
• 1083326-15-1 2-amino-5-bromo-N,N-dimethylpyridine-3-sulfonamide 
• 73183-34-3 bis(pinacol)diborane 
• 15862-34-7 5-bromo-3-nitro-1H-pyridin-2-one 

Downstream Products

• 97966-00-2 5-bromo-2,3-dichloropyridine 
• 1083326-17-3 N-(5-bromo-2-chloropyridin-3-yl)benzenesulfonamide 
• 1112982-79-2 N-(5-bromo-2-chloro-3-pyridinyl)-4-fluoro-N-((4-fluorophenyl)sulfonyl)benzenesulfonamide 
• 1112982-81-6 N-(5-bromo-2-chloropyridin-3-yl)-4-methoxybenzenesulfonamide 
• 1400668-14-5 N-(5-bromo-2-chloropyridin-3-yl)-2,4-difluorobenzamide 
• 1083326-21-9 N-(5-bromo-2-chloropyridin-3-yl )-2,4-difluorobenzenesulfonamide 
• 1268833-71-1 N-(6-(6-chloro-5-(2-chlorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide 
• 1268833-73-3 N-(5-bromo-2-chloropyridin-3-yl)-2-chlorobenzenesulfonamide 
• 1112980-87-6 N-(6-(6-chloro-5-(4-methoxyphenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide 
• 1112980-98-9 N-(6-(5-(3-tert-butylphenylsulfonamido)-6-chloropyridin-3-yl)benzo[d]thiazol-2-yl)acetamide 
• 1310049-08-1 C₁₅H₁₆BrClN₂O₂S 
• 1268833-70-0 N-(6-(6-chloro-5-(2-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide 
• 1310049-09-2 C₁₂H₇BrClF₃N₂O₂S 
• 1112980-97-8 N-(6-(6-chloro-5-(3-(trifluoromethyl)phenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide 

Relevant articles and documents

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.

NOVEL PYRIDOPYRIMIDINE DERIVATIVES AND USE THEREOF

The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3′ OH kinase family (PI3K) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders.

QUINAZOLINE DERIVATIVES AS PI3 KINASE INHIBITORS

Invented is a method of inhibiting the activity/function of P13 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinazoline derivatives.