2-Chloro-3-amino-5-bromopyridine

Base Information

• Chemical Name: 2-Chloro-3-amino-5-bromopyridine
• CAS No.: 588729-99-1
• Molecular Formula: C5H4BrClN2
• Molecular Weight: 207.457
• Hs Code.: 29333990
• Mol file: 588729-99-1.mol

Synonyms:5-Bromo-2-chloro-3-pyridinamine;5-Bromo-2-chloropyridin-3-amine;5-Bromo-2-chloro-pyridin-3-ylamine;3-Amino-5-bromo-2-chloropyridi;3-Amino-5-Bromo-2-Chloropyrid;

Chemical Property of 2-Chloro-3-amino-5-bromopyridine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 129-132℃
• Refractive Index: 1.648
• Boiling Point: 296.778 °C at 760 mmHg
• PKA: 0.03±0.10(Predicted)
• Flash Point: 133.287 °C
• PSA: 38.91000
• Density: 1.835 g/cm³
• LogP: 2.66090
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

3-Amino-5-bromo-2-chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-37/38-41-22
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-amino-5-bromopyridine

There total 9 articles about 2-Chloro-3-amino-5-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-2-chloro-3-nitropyridine (67443-38-3) → 3-amino-5-bromo-2-chloropyridine (588729-99-1)

Guidance literature:

With hydrogen; nickel; In methanol;

Reference yield: 86.0%

2-amino-5-bromo-N,N-dimethylpyridine-3-sulfonamide (1083326-15-1) + bis(pinacol)diborane (73183-34-3) → 3-amino-5-bromo-2-chloropyridine (588729-99-1)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 100 ℃; for 18h;

Reference yield:

5-bromo-3-nitro-pyridin-2-ylamine (6945-68-2) → 3-amino-5-bromo-2-chloropyridine (588729-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / tBuNO; CuCl₂ / acetonitrile / 2 h / Heating

2: 87 percent / SnCl₂*2H₂O / ethyl acetate / 3 h / Heating

With t-butylnitrite; tin(ll) chloride; copper dichloride; In ethyl acetate; acetonitrile;

DOI:10.1002/jhet.5570400210

upstream raw materials:

2,5-dibromopyridin-3-ylamine

5-bromo-2-chloro-3-nitropyridine

2,5-dibromo-3-nitro-pyridine

hydrogenchloride

Downstream raw materials:

5-bromo-2,3-dichloropyridine

2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine

N-(5-bromo-2-chloropyridin-3-yl)benzenesulfonamide

N-(5-bromo-2-chloro-3-pyridinyl)-4-fluoro-N-((4-fluorophenyl)sulfonyl)benzenesulfonamide