2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine

Base Information

Chemical Name:2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine
CAS No.:1430727-61-9
Molecular Formula:C₂₂H₁₆F₂N₆
Molecular Weight:402.406
Hs Code.:

Synonyms:2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine

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Chemical Property of 2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine

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Technology Process of 2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine

There total 14 articles about 2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1430723-47-9
N-(2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide

: 1430727-61-9
2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine

Guidance literature:: With sodium hydroxide; In ethanol; water; at 85 ℃; for 5h;

Reference yield:

: 364-75-0
1-fluoro-4-iodo-2-nitro-benzene

: 1430727-61-9
2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine

Guidance literature:: Multi-step reaction with 7 steps

1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

2: ammonium chloride; zinc / water; tetrahydrofuran / 0.5 h / 20 °C

3: 0.5 h / 100 °C

4: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

6: sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tetrahydrofuran; dimethyl sulfoxide / 12 h / 20 °C

7: sodium hydroxide / water; ethanol / 5 h / 85 °C

With potassium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; copper(ll) sulfate pentahydrate; tetrabutyl ammonium fluoride; ammonium chloride; sodium L-ascorbate; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430727-61-9
2',4'-difluoro-5-(5-(1-methyl-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-amine

Guidance literature:: Multi-step reaction with 11 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

5: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C

6: ammonium chloride; zinc / water; tetrahydrofuran / 0.5 h / 20 °C

7: 0.5 h / 100 °C

8: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

9: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

10: sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tetrahydrofuran; dimethyl sulfoxide / 12 h / 20 °C

11: sodium hydroxide / water; ethanol / 5 h / 85 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; copper(ll) sulfate pentahydrate; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; iron; sodium carbonate; ammonium chloride; acetic acid; sodium L-ascorbate; triethylamine; sodium hydroxide; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; acetic acid; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;