4-(8-methoxy-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)-N,N-dimethylaniline

Base Information

Chemical Name:4-(8-methoxy-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)-N,N-dimethylaniline
CAS No.:1412908-98-5
Molecular Formula:C₂₂H₁₉F₃N₄O
Molecular Weight:412.414
Hs Code.:

Synonyms:4-(8-methoxy-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)-N,N-dimethylaniline

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Chemical Property of 4-(8-methoxy-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)-N,N-dimethylaniline

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Technology Process of 4-(8-methoxy-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)-N,N-dimethylaniline

There total 1 articles about 4-(8-methoxy-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 586-77-6
4-bromo-N,N-dimethylaniline

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 63744-25-2
6-bromo-8-methoxyimidazo[1,2-a]pyrazine

: 1412908-98-5
4-(8-methoxy-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)-N,N-dimethylaniline

Guidance literature:: (meta-(trifluoromethyl)phenyl)boronic acid; 6-bromo-8-methoxyimidazo[1,2-a]pyrazine; With palladium diacetate; caesium carbonate; CyJohnPhos; In 1,4-dioxane; at 90 ℃; Inert atmosphere;

4-bromo-N,N-dimethylaniline; In 1,4-dioxane; at 120 ℃; Inert atmosphere; Sealed tube;
DOI:10.1021/ol3029059

Reference yield: 77.0%

: 1412908-98-5
4-(8-methoxy-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)-N,N-dimethylaniline

: 100-59-4
phenylmagnesium chloride

: 1412909-18-2
N,N-dimethyl-4-(8-phenyl-6-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-3-yl)aniline

Guidance literature:: With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere; Reflux;
DOI:10.1021/ol3029059