(tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester

Base Information

• Chemical Name: (tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester
• CAS No.: 135348-18-4
• Molecular Formula: C₁₆H₂₆O₃Si
• Molecular Weight: 294.466
• Mol file: 135348-18-4.mol

Synonyms:(tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester

Chemical Property of (tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester

There total 9 articles about (tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (S)-(-)-ethyl mandelate (13704-09-1) → (S)-(tert-butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester (135348-18-4)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1021/jo00021a007

Reference yield: 70.0%

ethanol (64-17-5) + (tert-Butyl-dimethyl-silanyloxy)-phenyl-acetyl bromide (105041-07-4) → (tert-Butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester (135348-18-4)

Guidance literature:

With pyridine; In dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1021/jo00375a034

Reference yield:

C16H25N2O3Si(1+)*BF4(1-) → (S)-(tert-butyl-dimethyl-silanyloxy)-phenyl-acetic acid ethyl ester (135348-18-4)

Guidance literature:

With hypophosphorous acid; copper(I) oxide; at 0 ℃; for 0.25h;

DOI:10.1021/ja002593j

upstream raw materials:

tert-butyldimethylsilyl chloride

(S)-(-)-ethyl mandelate

t-butyldimethylsiyl triflate

(S)-2-[4-(dimethylamino)phenyl]-2-hydroxyacetic acid ethyl ester

Downstream raw materials:

Benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine

2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde