N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide

Base Information

Chemical Name:N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide
CAS No.:1304777-60-3
Molecular Formula:C₄₇H₈₁N₅O₁₁
Molecular Weight:892.187
Hs Code.:

Synonyms:N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide

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Technology Process of N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide

There total 2 articles about N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1304777-57-8
Nα-[benzyloxycarbonyl]-N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide

: 1304777-60-3
N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; for 22h; under 3620.13 Torr;
DOI:10.1002/chem.201002976

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: [N⁽²⁾,N⁽²⁾-bis[2-[bis(1,1-dimethylethoxy)-2-oxoethyl]amino]-ethyl]-L-lysine 1,1-dimethylethyl ester

: 1304777-60-3
N'-[5-tert-butoxycarbonyl-5-(bis[2-{bis(tert-butoxycarbonylmethyl)amino}ethyl]amino)pentyl]-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 22 h / 3620.13 Torr

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/chem.201002976