H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA

Base Information

Chemical Name:H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA
CAS No.:118892-04-9
Molecular Formula:C₂HF₃O₂*C₁₇H₂₆N₃O₈P
Molecular Weight:545.406
Hs Code.:

H-Tyr(PO<sub>3</sub>H<sub>2</sub>)-Leu-Gly-OH*TFA

Synonyms:H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA

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Technology Process of H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA

There total 4 articles about H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: 118920-14-2
Boc-Tyr(PO₃Bzl₂)-Leu-Gly-OBzl

: 76-05-1
trifluoroacetic acid

: 118892-04-9
H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 0.5h; under 760 Torr;
DOI:10.1021/jo00268a047

Reference yield:

: 92264-98-7
N-(tert-butoxycarbonyl)-O-(dibenzylphosphono)-L-tyrosyl p-nitro-benzyl ester

: 118892-04-9
H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / Na₂S₂O₄ / 1 h / 50 °C / pH 8.6

2: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -20 deg C, 3 min, 2.) -20 deg C, 2 h

3: 99.5 percent / H₂ / 10percent Pd/C / acetic acid / 0.5 h / 760 Torr

With 4-methyl-morpholine; sodium dithionite; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In acetic acid;
DOI:10.1021/jo00268a047

Reference yield:

: 92265-01-5
N^α-(tert-butoxycarbonyl)-O-(O',O''-dibenzylphosphoro)-L-tyrosine

: 118892-04-9
H-Tyr(PO₃H₂)-Leu-Gly-OH*TFA

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -20 deg C, 3 min, 2.) -20 deg C, 2 h

2: 99.5 percent / H₂ / 10percent Pd/C / acetic acid / 0.5 h / 760 Torr

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In acetic acid;
DOI:10.1021/jo00268a047