1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil

Base Information

Chemical Name:1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil
CAS No.:664333-54-4
Molecular Formula:C₃₃H₃₄N₂O₈
Molecular Weight:586.642
Hs Code.:

Synonyms:1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil

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Chemical Property of 1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil

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Technology Process of 1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil

There total 6 articles about 1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 664333-53-3
1-(2-O,2-C-propano-β-D-arabinofuranosyl)uracil

: 664333-54-4
1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil

Guidance literature:: With pyridine; at 20 ℃; for 12h;
DOI:10.1039/b306354b

Reference yield:

: 84828-97-7
1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione

: 664333-54-4
1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil

Guidance literature:: Multi-step reaction with 6 steps

1.1: CeCl₃*7H₂O / tetrahydrofuran; diethyl ether / 2 h / -78 °C

1.2: 75 percent / tetrahydrofuran; diethyl ether / 2 h / -78 °C

2.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / 20 °C

2.2: 64 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 2 h / 20 °C

3.1: 74 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: 76 percent / NaH / tetrahydrofuran / 2 h / 20 °C

5.1: 91 percent / Et₃N*3HF / acetonitrile; tetrahydrofuran / 2 h / 20 °C

6.1: 100 percent / pyridine / 12 h / 20 °C

With pyridine; cerium(III) chloride; sodium hydride; triethylamine tris(hydrogen fluoride); 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; 1.2: Grignard addition;
DOI:10.1039/b306354b

Reference yield:

: 664333-52-2
1-[2-O,2-C-propano-3,5-di-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-arabinofuranosyl]uracil

: 664333-54-4
1-[5-O-(4,4'-dimethoxytrityl)-2-O,2-C-propano-β-D-arabinofuranosyl]uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Et₃N*3HF / acetonitrile; tetrahydrofuran / 2 h / 20 °C

2: 100 percent / pyridine / 12 h / 20 °C

With pyridine; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; acetonitrile;
DOI:10.1039/b306354b