tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate

Base Information

Chemical Name:tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate
CAS No.:1613157-64-4
Molecular Formula:C₃₃H₅₇NO₅Si
Molecular Weight:575.905
Hs Code.:

Synonyms:tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate

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Chemical Property of tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate

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Technology Process of tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate

There total 3 articles about tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1613157-61-1
N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine

: 1613157-64-4
tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate

Guidance literature:: With dmap; triethylamine; In acetonitrile; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.040

Reference yield:

: 213964-79-5
3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propanal

: 1613157-64-4
tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium cyanoborohydride / acetonitrile / 12 h / 20 °C / pH 6 / Inert atmosphere

2: triethylamine; dmap / acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium cyanoborohydride; acetic acid; triethylamine; In acetonitrile;
DOI:10.1016/j.bmc.2014.04.040

Reference yield:

: 100-46-9
benzylamine

: 1613157-64-4
tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium cyanoborohydride / acetonitrile / 12 h / 20 °C / pH 6 / Inert atmosphere

2: triethylamine; dmap / acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium cyanoborohydride; acetic acid; triethylamine; In acetonitrile;
DOI:10.1016/j.bmc.2014.04.040