2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid

Base Information

Chemical Name:2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid
CAS No.:1613157-73-5
Molecular Formula:C₂₇H₄₁NO₆
Molecular Weight:475.626
Hs Code.:

Synonyms:2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid

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Chemical Property of 2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid

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Technology Process of 2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid

There total 6 articles about 2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613157-70-2
C₂₇H₄₁NO₅

: 1613157-73-5
2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmc.2014.04.040

Reference yield:

: 213964-79-5
3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propanal

: 1613157-73-5
2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; sodium cyanoborohydride / acetonitrile / 12 h / 20 °C / pH 6 / Inert atmosphere

2: triethylamine; dmap / acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

5: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 3 h / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; sodium cyanoborohydride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmc.2014.04.040

Reference yield:

: 1613157-61-1
N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine

: 1613157-73-5
2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; dmap / acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

4: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 3 h / 0 - 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmc.2014.04.040