N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine

Base Information

• Chemical Name: N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine
• CAS No.: 1613157-61-1
• Molecular Formula: C₂₈H₄₉NO₃Si
• Molecular Weight: 475.787
• Mol file: 1613157-61-1.mol

Synonyms:N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine

Chemical Property of N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine

There total 1 articles about N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzylamine (100-46-9) + 3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propanal (213964-79-5) → N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine (1613157-61-1)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In acetonitrile; at 20 ℃; for 12h; pH=6; Inert atmosphere;

DOI:10.1016/j.bmc.2014.04.040

Reference yield: 73.0%

di-tert-butyl dicarbonate (24424-99-5) + N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine (1613157-61-1) → tert-butyl benzyl(3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propyl)carbamate (1613157-64-4)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.04.040

Reference yield:

N-benzyl-3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propan-1-amine (1613157-61-1) → C20H27NO2 (1613157-76-8)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine; dmap / acetonitrile / 12 h / 0 - 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

4: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 3 h / 0 - 20 °C

5: acetic acid / water / 12 h / 100 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;

DOI:10.1016/j.bmc.2014.04.040

upstream raw materials:

benzylamine

3-((6S,7R)-7-(2-((tert-butyldimethylsilyl)oxy)ethyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-6-yl)propanal

Downstream raw materials:

C₂₀H₂₇NO₂

C₂₇H₄₃NO₅

C₂₇H₄₁NO₅

2-((6S,7R)-6-(3-(benzyl(tert-butoxycarbonyl)amino)propyl)-6,7-dimethyl-1,4-dioxaspiro[4.5]decan-7-yl)acetic acid