(R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester

Base Information

Chemical Name:(R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester
CAS No.:340963-62-4
Molecular Formula:C₃₂H₃₈N₂O₇Si
Molecular Weight:590.748
Hs Code.:

Synonyms:(R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester

Suppliers and Price of (R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester

There total 9 articles about (R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 340963-60-2
(R)-allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]amine

: 13831-31-7
Acetoxyacetyl chloride

: 340963-62-4
(R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester

Guidance literature:: With triethylamine; In diethyl ether; at 0 - 20 ℃;
DOI:10.1021/jo015512q

Reference yield:

: 82807-38-3
1-(2-methoxyphenyl)ethane-1,2-diol

: 340963-62-4
(R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / pyridine / 8 h / 20 °C

2: 83 percent / KNO₃; TFAA / CHCl₃ / 48 h / 0 °C

3: 93 percent / K₂CO₃ / methanol; H₂O / 0.5 h

4: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

5: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

6: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

7: 78 percent / 4 Angstroem MS; CsOH*H₂O / dimethylformamide

8: 86 percent / Et₃N / diethyl ether / 0 - 20 °C

With 1H-imidazole; cesium hydroxide; 4 Angstroem MS; potassium carbonate; hydrazine hydrate; potassium nitrate; triethylamine; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; chloroform; water; N,N-dimethyl-formamide; 5: Mitsunobu reaction;
DOI:10.1021/jo015512q

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 340963-62-4
(R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

3: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

4: 78 percent / 4 Angstroem MS; CsOH*H₂O / dimethylformamide

5: 86 percent / Et₃N / diethyl ether / 0 - 20 °C

With 1H-imidazole; cesium hydroxide; 4 Angstroem MS; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jo015512q