2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole
CAS No.:1312793-99-9
Molecular Formula:C₁₉H₂₅N₃O₃
Molecular Weight:343.426
Hs Code.:

Synonyms:2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

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Chemical Property of 2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Chemical Property:

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Technology Process of 2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

There total 4 articles about 2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1312793-98-8
tert-butyl 4-(2-(3-cyclopentyloxy-4-methoxybenzoyl)hydrazinecarbonyl)piperidine-1-carboxylate

: 1312793-99-9
2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Guidance literature:: With thionyl chloride; In benzene; Reflux;
DOI:10.1016/j.ejmech.2011.03.031

Reference yield:

: 2971-79-1
isonipecotic acid methyl ester

: 1312793-99-9
2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water

2: hydrazine / methanol / Reflux

3: triethylamine / N,N-dimethyl-formamide / 5 h / 0 - 30 °C

4: thionyl chloride / benzene / Reflux

With thionyl chloride; sodium hydrogencarbonate; triethylamine; hydrazine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.ejmech.2011.03.031

Reference yield:

: 124443-68-1
1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate

: 1312793-99-9
2-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / methanol / Reflux

2: triethylamine / N,N-dimethyl-formamide / 5 h / 0 - 30 °C

3: thionyl chloride / benzene / Reflux

With thionyl chloride; triethylamine; hydrazine; In methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.ejmech.2011.03.031