N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide

Base Information

Chemical Name:N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide
CAS No.:1589554-34-6
Molecular Formula:C₁₇H₂₂N₂O₅S
Molecular Weight:366.438
Hs Code.:

Synonyms:N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide

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Chemical Property of N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide

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Technology Process of N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide

There total 3 articles about N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1589556-08-0
(3R,11R,E)-11-amino-3-phenyl-1-oxa-4-azacyclododec-8 ene-5,12-dione trifluoroacetate

: 124-63-0
methanesulfonyl chloride

: 1589554-34-6
N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1589556-07-9
tert-butyl ((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11-yl)carbamate

: 1589554-34-6
N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylsilane / dichloromethane / 4 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

With triethylsilane; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1589558-50-8
tert-butyl ((4R,8S)-5-oxo-8-(pent-4-enamido)-8-phenyloct-1-en-4-yl)carbamate

: 1589554-34-6
N-((3R,11R,E)-5,12-dioxo-3-phenyl-1-oxa-4-azacyclododec-8-en-11yl)-methane sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 3-carboxy-2-mercaptopyridine / dichloromethane / 3 h / 20 °C

2: triethylsilane / dichloromethane / 4 h / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; triethylsilane; 3-carboxy-2-mercaptopyridine; triethylamine; In dichloromethane; N,N-dimethyl-formamide;