(-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide

Base Information

Chemical Name:(-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide
CAS No.:237406-06-3
Molecular Formula:C₁₈H₂₂BrNO₂
Molecular Weight:364.282
Hs Code.:

Synonyms:(-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide

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Technology Process of (-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide

There total 5 articles about (-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 185851-32-5
(+)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene carboxamide

: 237406-06-3
(-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide

Guidance literature:: With CrO₃-3.5-dimethylpyrazole; In dichloromethane; at -15 ℃;
DOI:10.1016/S0040-4039(96)02159-4

Reference yield:

: 4773-87-9
3-bromo-2,4-dimethylpenta-1,3-diene

: 237406-06-3
(-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / 48 h / Heating

2: 32 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) 0 deg C to room temp., 1 h

3: 45 percent / Na, 2-propanol / tetrahydrofuran / 168 h / 80 °C

4: 76 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / 18 h / -15 °C

With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; sodium; triethylamine; isopropyl alcohol; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(99)00305-1

Reference yield:

: 185851-20-1
3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride

: 237406-06-3
(-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene-4-one carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 32 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) 0 deg C to room temp., 1 h

2: 45 percent / Na, 2-propanol / tetrahydrofuran / 168 h / 80 °C

3: 76 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / 18 h / -15 °C

With 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; sodium; triethylamine; isopropyl alcohol; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(99)00305-1