3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride

Base Information

• Chemical Name: 3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride
• CAS No.: 185851-20-1
• Molecular Formula: C₁₀H₁₄BrClO
• Molecular Weight: 265.578
• Mol file: 185851-20-1.mol

Synonyms:3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride

Chemical Property of 3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride

There total 1 articles about 3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-bromo-2,4-dimethylpenta-1,3-diene (4773-87-9) + acryloyl chloride (814-68-6,25189-84-8) → 3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride (185851-20-1)

Guidance literature:

at 110 ℃;

DOI:10.1016/S0040-4039(96)02159-4

Reference yield: 94.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride (185851-20-1) → C12H20BrNO2 (1426819-10-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetlet.2013.01.115

Reference yield: 32.0%

(S)-1-phenyl-ethylamine (2627-86-3) + 3-bromo-2,2,4-trimethylcyclohex-3-ene carbonyl chloride (185851-20-1) → (-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene carboxamide (185851-21-2) + (+)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene carboxamide (185851-32-5)

Guidance literature:

With triethylamine; In dichloromethane; 1.) 0 deg C, 30 min, 2.) 0 deg C to room temp., 1 h;

DOI:10.1016/S0040-4020(99)00305-1

upstream raw materials:

3-bromo-2,4-dimethylpenta-1,3-diene

acryloyl chloride

Downstream raw materials:

(-)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene carboxamide

(+)-N-(α-methylbenzyl)-3-bromo-2,2,4-trimethylcyclohex-3-ene carboxamide

(+)-methyl 3-bromo-5α-hydroxy-2,2,4-trimethylcyclohex-3-ene carboxylate

(+)-methyl 3-bromo-2,2,4-trimethylcyclohex-3-ene-5-one carboxylate