C₄₁H₆₈O₈Si

Base Information

Chemical Name:C₄₁H₆₈O₈Si
CAS No.:142459-50-5
Molecular Formula:C₄₁H₆₈O₈Si
Molecular Weight:717.072
Hs Code.:

C<sub>41</sub>H<sub>68</sub>O<sub>8</sub>Si

Synonyms:C₄₁H₆₈O₈Si

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Chemical Property of C₄₁H₆₈O₈Si

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Technology Process of C₄₁H₆₈O₈Si

There total 61 articles about C₄₁H₆₈O₈Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142459-13-0
(E)-(4R,5S)-4-Acetoxy-5-(methanesulfonyloxy)-2-hexenal

: 142459-50-5
C₄₁H₆₈O₈Si

Guidance literature:: Multi-step reaction with 17 steps

1: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

2: methanol / 9.5 h / 5 °C

3: imidazole / dimethylformamide / 1 h / Ambient temperature

4: 93 percent / BF₃*OEt₂ / CH₂Cl₂ / 1 h / 0 °C

5: 83 percent / Bu₄NF / tetrahydrofuran

6: 1) NaH / 1) THF 2) r.t., 1 h

7: 99 percent / DIBALH / hexane; diethyl ether / 0.08 h

8: 1) oxalyl chloride, DMSO, 2) Et₃N / 1) CH₂Cl₂, -80 deg C - 60 deg C, 1 h, 2) - 40 deg C, 30 min

9: NaClO₂, 2-methyl-2-butene, NaH₂PO₄*2H₂O / 2-methyl-propan-2-ol / 0.33 h / Ambient temperature

10: 142 mg / diethyl ether

11: 1.23 g / LDA / tetrahydrofuran; hexane / 0.58 h / -100 °C

12: 1.17 g / DMAP, pyridine / 48 h / Ambient temperature

13: 1,8-diazabicyclo<5.4.0>undec-7-ene / 48 h / Ambient temperature

14: acetone / Irradiation

15: 50 mg / DIBALH / toluene; hexane / 0.58 h / -80 - -70 °C

16: 44 mg / imidazole, Et₃N / CH₂Cl₂ / 0.58 h / Ambient temperature

17: 1) LDA, 2) N,N'-dimethylpropyleneurea / 1) THF, hexane, 2) THF, -100 deg C - -95 deg C, 20 min

With pyridine; 1H-imidazole; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/jo00036a026

Reference yield:

: 124908-71-0
3-Methoxy-5-methyl-cyclohexa-2,5-dienecarboxylic acid

: 142459-50-5
C₄₁H₆₈O₈Si

Guidance literature:: Multi-step reaction with 21 steps

1: diethyl ether

2: 8.28 g / DIBALH / hexane; diethyl ether / 1.5 h / -50 °C

3: 12.4 g / imidazole / CH₂Cl₂ / 0.25 h

4: 1) 2,6-di-tert-butylcresol, dichloromaleic anhydride 2) NaOMe / 1) chlorobenzene, 150 deg C, 24 h 2) MeOH, 0 deg C, 50 min

5: HF / acetonitrile / 1 h / 0 °C / Resolution: 1) isooctane, benzene, (Ac)2O, Amano lipase CES on Celite, 23 deg C, 5 h, 2) chromatography (silica gel, AcOEt/hexane), 3) recrystallization (Et₂O)

6: 99 percent / imidazole / CH₂Cl₂ / 1 h / Ambient temperature

7: 69 percent / 1) lithium hexamethyldisilazane, 2) HMPA / 1) THF, hexane, -50 deg C - -60 deg C, 1 h, 2) -35 deg C, 24 h

8: 98 percent / NH₂OH*HCl, pyridine / CH₂Cl₂ / 15 h / Heating

9: 1) TsCl, DMAP, pyridine, 2) LiCl, MeOH / 1) CH₂Cl₂, -80 deg C - r.t., 1 h, 2) r.t., 2 weeks

10: 72 percent / H₂ / 10percent Pd/C / ethanol

11: ethanol / 1.5 h / Heating

12: 627 mg / catecholborane, NaOAc*3H₂O / CHCl₃; tetrahydrofuran / 48 h / Heating

13: 473 mg / 5percent HF / acetonitrile / 0.75 h / 0 °C

14: 1) oxalyl chloride, DMSO, 2) Et₃N / 1) CH₂Cl₂, -80 deg C - -60 deg C, 1 h, 2) -60 deg C, 50 min

15: 1.23 g / LDA / tetrahydrofuran; hexane / 0.58 h / -100 °C

16: 1.17 g / DMAP, pyridine / 48 h / Ambient temperature

17: 1,8-diazabicyclo<5.4.0>undec-7-ene / 48 h / Ambient temperature

18: acetone / Irradiation

19: 50 mg / DIBALH / toluene; hexane / 0.58 h / -80 - -70 °C

20: 44 mg / imidazole, Et₃N / CH₂Cl₂ / 0.58 h / Ambient temperature

21: 1) LDA, 2) N,N'-dimethylpropyleneurea / 1) THF, hexane, 2) THF, -100 deg C - -95 deg C, 20 min

With pyridine; 1H-imidazole; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromaleic acid anhydride; oxalyl dichloride; 2,4-di-t-butyl-3-methyl phenol; hydrogen fluoride; hydroxylamine hydrochloride; hydrogen; sodium methylate; sodium acetate; diisobutylaluminium hydride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; p-toluenesulfonyl chloride; lithium chloride; lithium hexamethyldisilazane; lithium diisopropyl amide; benzo[1,3,2]dioxaborole; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; chloroform; acetone; toluene; acetonitrile;
DOI:10.1021/jo00036a026

Reference yield:

: 142560-63-2
(4S,5S)-5-<<(tert-Butyldimethylsilyl)oxy>-methyl>-4-<(1R)-1-cyanoethyl>-3-methylcyclohex-2-en-1-one

: 142459-50-5
C₄₁H₆₈O₈Si

Guidance literature:: Multi-step reaction with 12 steps

1: 72 percent / H₂ / 10percent Pd/C / ethanol

2: ethanol / 1.5 h / Heating

3: 627 mg / catecholborane, NaOAc*3H₂O / CHCl₃; tetrahydrofuran / 48 h / Heating

4: 473 mg / 5percent HF / acetonitrile / 0.75 h / 0 °C

5: 1) oxalyl chloride, DMSO, 2) Et₃N / 1) CH₂Cl₂, -80 deg C - -60 deg C, 1 h, 2) -60 deg C, 50 min

6: 1.23 g / LDA / tetrahydrofuran; hexane / 0.58 h / -100 °C

7: 1.17 g / DMAP, pyridine / 48 h / Ambient temperature

8: 1,8-diazabicyclo<5.4.0>undec-7-ene / 48 h / Ambient temperature

9: acetone / Irradiation

10: 50 mg / DIBALH / toluene; hexane / 0.58 h / -80 - -70 °C

11: 44 mg / imidazole, Et₃N / CH₂Cl₂ / 0.58 h / Ambient temperature

12: 1) LDA, 2) N,N'-dimethylpropyleneurea / 1) THF, hexane, 2) THF, -100 deg C - -95 deg C, 20 min

With pyridine; 1H-imidazole; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; oxalyl dichloride; hydrogen fluoride; hydrogen; sodium acetate; diisobutylaluminium hydride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; benzo[1,3,2]dioxaborole; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; acetone; toluene; acetonitrile;
DOI:10.1021/jo00036a026